Atthebeginningof2259,CaptainJohnSheridanreplacesSinclairasthemilitarygovernorofthestationHeandthecommandstafflearnthatthedeathofPresidentSantiagowasactuallyanassassinationmastermindedbyVicePresidentClarkwhoassumedthePresidencyuponSantiago'sdeathAconflictdevelopsbetweentheBabylon5commandstaffandthePsiCorps,anincreasinglyautocraticorganizationwhichoverseesandcontrolsthelivesofhumantelepathsCommanderIvanova,thesecondincommandofthestation,issecretlyalatenttelepathwhohasillicitlyavoidedregisteringwiththePsiCorps  
TheShadows,anancientandextremelypowerfulracewhohaverecentlyemergedfromhibernation,arerevealedtobethecauseofavarietyofmysteriousanddisturbingevents,includingtheattackontheNarnoutpostattheendof2258CentauriAmbassadorLondoMollariunknowinglyenliststheiraidthroughhisassociationwiththemysteriousMrMordenintheongoingconflictwiththeNarnTheelderlyandailingCentauriemperor,longanadvocateofreconciliationwiththeNarn,diessuddenlywhilevisitingBabylon5Anumberofconspirators,includingLondoMollariandRefa,takecontroloftheCentaurigovernmentbyassassinatingtheiropponentsandplacingthelateemperor'sunstablenephewonthethroneTheirfirstactistostartopenaggressionagainsttheNarnAfterafullscalewarbreaksout,theCentaurieventuallyconquerNarninabrutalattackinvolvingmassdrivers,outlawedweaponsofmassdestructionTowardstheendoftheyear,theClarkadministrationbeginstoshowincreasinglytotalitariancharacteristics,clampingdownondissentandrestrictingfreedomofspeechTheVorlonsarerevealedtobethebasisoflegendsaboutangelsonvariousworlds,includingEarth,andaretheancientenemiesoftheShadowsTheyenlisttheaidofSheridanandtheBabylon5commandstaffinthestruggleagainsttheShadows
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